[et_pb_section fb_built=”1″ custom_padding_last_edited=”on|phone” _builder_version=”4.27.4″ _module_preset=”default” use_background_color_gradient=”on” background_color_gradient_direction=”90deg” background_color_gradient_stops=”rgba(10,0,0,0.64) 0%|rgba(10,2,2,0) 75%” background_color_gradient_overlays_image=”on” background_image=”https:\/\/lowcountrymale.com\/wp-content\/uploads\/2024\/08\/sleep-and-testosterone-scaled.jpeg” width=”90%” module_alignment=”center” custom_margin=”50px||||false|false” custom_padding=”75px||75px|50px|true|false” custom_padding_tablet=”75px||75px|50px|true|false” custom_padding_phone=”45px|25px|45px|25px|true|true” background_last_edited=”on|phone” use_background_color_gradient_phone=”on” background_color_gradient_stops_phone=”rgba(10,0,0,0.64) 0%|rgba(10,2,2,0.25) 76%” background_position_phone=”center_right” background_horizontal_offset_phone=”32%” border_radii=”on|25px|25px|25px|25px” global_colors_info=”{}”][et_pb_row custom_padding_last_edited=”on|desktop” _builder_version=”4.27.4″ _module_preset=”default” background_color=”rgba(0,0,0,0.33)” width=”55%” width_tablet=”55%” width_phone=”95%” width_last_edited=”on|phone” max_width_tablet=”” max_width_phone=”95%” max_width_last_edited=”on|phone” module_alignment=”left” custom_padding=”100px||100px||true|false” custom_padding_tablet=”35px||35px||true|false” custom_padding_phone=”35px||35px||true|false” module_alignment_tablet=”left” module_alignment_phone=”center” module_alignment_last_edited=”on|phone” border_radii=”on|10px|10px|10px|10px” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” text_font=”|600|||||||” text_text_color=”#ffffff” text_font_size=”16px” header_font=”Montserrat|800|||||||” header_text_color=”#ffffff” header_font_size=”36px” custom_padding=”|3%||3%|false|true” custom_padding_tablet=”|4%||4%|false|true” custom_padding_phone=”|4%||4%|false|true” custom_padding_last_edited=”on|phone” header_text_align_tablet=”left” header_text_align_phone=”center” header_text_align_last_edited=”on|phone” header_font_size_tablet=”36px” header_font_size_phone=”30px” header_font_size_last_edited=”on|phone” global_colors_info=”{}”]<\/p>\n
At Lowcountry Male<\/a>, we\u2019re committed to exploring innovative approaches to enhance longevity and quality of life. One such avenue gaining attention is the use of metformin – a well-established medication traditionally used to manage type 2 diabetes. Emerging research suggests metformin may hold potential as an anti-aging agent, offering benefits that extend beyond blood sugar control. Here\u2019s a closer look at how metformin could play a role in promoting healthy aging.<\/span><\/p>\n [\/et_pb_text][et_pb_button button_url=”https:\/\/lowcountrymale.com\/100-off-consultation\/” url_new_window=”on” button_text=”$100 Off First Consultation” button_alignment=”left” button_alignment_tablet=”center” button_alignment_phone=”center” button_alignment_last_edited=”on|desktop” _builder_version=”4.27.4″ _module_preset=”default” custom_button=”on” button_text_color=”#ffffff” button_bg_color=”#F26522″ button_border_width=”0px” button_font=”Montserrat|700|||||||” custom_margin=”|||20px|false|false” custom_margin_tablet=”|||20px|false|false” custom_margin_phone=”|10px||10px|false|false” custom_margin_last_edited=”on|phone” custom_padding=”||||false|false” button_text_size_tablet=”” button_text_size_phone=”17px” button_text_size_last_edited=”on|desktop” locked=”off” global_colors_info=”{}” custom_css_main_element_last_edited=”on|phone” custom_css_main_element_phone=”line-height:1.25em!important;”][\/et_pb_button][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ custom_padding_last_edited=”on|phone” _builder_version=”4.27.4″ _module_preset=”default” custom_padding=”75px||75px||true|false” custom_padding_tablet=”50px||70px||false|false” custom_padding_phone=”40px||60px||false|false” global_colors_info=”{}”][et_pb_row custom_padding_last_edited=”on|phone” _builder_version=”4.27.4″ _module_preset=”default” max_width=”100%” custom_padding=”0px|50px|0px|50px|true|true” custom_padding_tablet=”0px|50px|0px|50px|true|true” custom_padding_phone=”|0px||0px|true|true” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.27.4″ _module_preset=”default” custom_padding_tablet=”||||false|true” custom_padding_last_edited=”off|desktop” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” text_font=”|600|||||||” text_text_color=”#3f3f3f” text_font_size=”16px” header_font=”Montserrat|800|||||||” header_text_color=”#ffffff” header_font_size=”36px” header_2_font=”Montserrat|800|||||||” header_2_text_color=”#4E738A” header_2_font_size=”30px” width=”100%” custom_padding_tablet=”||||false|true” custom_padding_last_edited=”off|tablet” text_orientation_tablet=”left” text_orientation_phone=”center” text_orientation_last_edited=”on|phone” global_colors_info=”{}”]<\/p>\n Metformin is a prescription medication primarily used to improve insulin sensitivity and regulate blood glucose levels in individuals with type 2 diabetes. Derived from the French lilac plant, it has been a cornerstone of diabetes treatment for decades due to its safety profile and efficacy. However, its mechanisms of action\u2014particularly its effects on cellular processes\u2014have sparked interest in its potential to address aging.<\/span>[\/et_pb_text][et_pb_audio audio=”https:\/\/lowcountrymale.com\/wp-content\/uploads\/2025\/08\/Metformin__Unlocking_Longevity_and_Surprising_Benefits_Beyond_Diabetes.mp3″ title=”\ud83c\udf99\ufe0f Listen & Learn: The Truth About Metformin” album_name=”Explore the latest research on metformin and its potential role in healthy aging. Learn how this well-studied medication may support longevity, metabolic health, and overall vitality. Tune in to our expert-led podcast interview for insights on benefits, safety, and what to expect on your wellness journey. Listen now.” _builder_version=”4.27.4″ _module_preset=”default” title_level=”h3″ title_font=”Montserrat|700|||||||” title_text_color=”#F26522″ title_font_size=”34px” caption_font=”Montserrat||||||||” caption_text_align=”center” caption_text_color=”#000000″ caption_font_size=”22px” background_color=”rgba(78,115,138,0.08)” background_layout=”light” custom_margin=”||2%||false|true” custom_padding=”||||false|false” title_text_shadow_style=”preset3″ title_text_shadow_blur_strength=”0.1em” border_radii=”on|10px|10px|10px|10px” border_width_all=”2px” border_color_all=”#4E738A” locked=”off” global_colors_info=”{}”][\/et_pb_audio][et_pb_button button_url=”https:\/\/lowcountrymale.com\/wp-content\/uploads\/2025\/08\/Metformin__Unlocking_Longevity_and_Surprising_Benefits_Beyond_Diabetes.m4a.zip” url_new_window=”on” button_text=”DOWNLOADABLE AUDIO” button_alignment=”center” module_id=”et-download-button” _builder_version=”4.27.4″ _module_preset=”default” custom_button=”on” button_text_size=”20px” button_text_color=”#ffffff” button_bg_color=”#4E738A” button_border_width=”0px” button_border_radius=”5px” button_font=”Montserrat|700|||||||” custom_margin=”0px|13%||13%|false|true” custom_margin_tablet=”0px|13%||13%|false|true” custom_margin_phone=”0px|13%||13%|false|true” custom_margin_last_edited=”on|desktop” custom_padding=”||||false|false” button_text_size_tablet=”16px” button_text_size_phone=”14px” button_text_size_last_edited=”on|phone” locked=”off” global_colors_info=”{}”][\/et_pb_button][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ custom_padding_last_edited=”on|phone” _builder_version=”4.27.4″ _module_preset=”default” background_color=”#e4eaed” use_background_color_gradient=”on” background_color_gradient_stops=”#e4eaed 38%|#ffffff 68%” custom_padding=”0px||||false|false” custom_padding_tablet=”||||false|false” custom_padding_phone=”||0px||false|false” locked=”off” global_colors_info=”{}”][et_pb_row _builder_version=”4.27.4″ _module_preset=”default” position_origin_a=”top_center” vertical_offset=”-20px” width=”100%” module_alignment=”center” custom_margin=”||||false|false” custom_padding=”20px||0px||false|false” custom_css_main_element=”text-align:center;” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” text_font=”|600|||||||” text_text_color=”#3f3f3f” text_font_size=”16px” header_font=”Montserrat|800|||||||” header_text_color=”#ffffff” header_font_size=”36px” header_2_font=”Montserrat|800|||||||” header_2_text_align=”center” header_2_text_color=”#ffffff” header_2_font_size=”30px” header_3_font=”Montserrat|800|||||||” header_3_text_align=”center” header_3_text_color=”#ffffff” header_3_font_size=”30px” background_color=”#4E738A” positioning=”relative” width_tablet=”” width_phone=”80%” width_last_edited=”on|phone” custom_margin=”-25px||15px||false|false” custom_margin_tablet=”-25px||15px||false|false” custom_margin_phone=”-25px||15px||false|false” custom_margin_last_edited=”on|phone” custom_padding=”10px|50px|5px|50px|false|true” header_2_font_size_tablet=”30px” header_2_font_size_phone=”24px” header_2_font_size_last_edited=”on|phone” header_3_font_size_tablet=”30px” header_3_font_size_phone=”24px” header_3_font_size_last_edited=”on|phone” custom_css_main_element=”display:inline-block;||justify-content:center!important;||text-align:center;” border_radii=”on|15px|15px|15px|15px” global_colors_info=”{}”]<\/p>\n [\/et_pb_text][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” text_font=”|700|||||||” text_font_size=”16px” custom_padding_tablet=”|12%||12%|false|true” custom_padding_phone=”|12%||12%|false|true” custom_padding_last_edited=”on|phone” text_orientation_tablet=”center” text_orientation_phone=”center” text_orientation_last_edited=”on|phone” global_colors_info=”{}”]<\/p>\n Aging is driven by complex biological processes, including inflammation, oxidative stress, and cellular damage. Metformin appears to influence several pathways that could counteract these effects, potentially promoting healthier aging. Here are the key mechanisms:<\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_3,1_3,1_3″ use_custom_gutter=”on” gutter_width=”2″ make_equal=”on” custom_padding_last_edited=”on|phone” _builder_version=”4.27.4″ _module_preset=”default” width=”90%” max_width=”100%” custom_margin=”1%||||false|false” custom_padding=”0px|50px|0px|50px|true|true” custom_padding_tablet=”|0px|30px|0px|false|true” custom_padding_phone=”|19px||19px|true|true” global_colors_info=”{}”][et_pb_column type=”1_3″ _builder_version=”4.27.4″ _module_preset=”default” background_color=”#ffffff” custom_padding=”35px|35px|35px|35px|true|true” border_radii=”on|10px|10px|10px|10px” border_width_all=”1px” border_color_all=”#4E738A” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” header_4_font_size=”22px” global_colors_info=”{}”]<\/p>\n [\/et_pb_text][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”4.27.4″ _module_preset=”default” background_color=”#ffffff” custom_padding=”35px|35px|35px|35px|true|true” border_radii=”on|10px|10px|10px|10px” border_width_all=”1px” border_color_all=”#4E738A” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” header_4_font_size=”22px” global_colors_info=”{}”]<\/p>\n Insulin resistance increases with age and is linked to chronic diseases such as cardiovascular disease and dementia. By enhancing insulin sensitivity, metformin may help maintain metabolic health, a key factor in healthy aging.<\/span><\/p>\n [\/et_pb_text][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”4.27.4″ _module_preset=”default” background_color=”#ffffff” custom_padding=”35px|35px|35px|35px|true|true” border_radii=”on|10px|10px|10px|10px” border_width_all=”1px” border_color_all=”#4E738A” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” header_4_font_size=”22px” global_colors_info=”{}”]<\/p>\n Chronic low-grade inflammation, often called \u201cinflammaging<\/a>,\u201d is a hallmark of aging. Metformin reduces the production of pro-inflammatory molecules, potentially mitigating inflammation-related damage to tissues and organs.<\/span><\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_2,1_2″ use_custom_gutter=”on” gutter_width=”2″ make_equal=”on” custom_padding_last_edited=”on|phone” _builder_version=”4.27.4″ _module_preset=”default” width=”90%” max_width=”100%” custom_margin=”1%||||false|false” custom_padding=”0px|50px|0px|50px|true|true” custom_padding_tablet=”|0px||0px|true|true” custom_padding_phone=”|19px||19px|true|true” global_colors_info=”{}”][et_pb_column type=”1_2″ _builder_version=”4.27.4″ _module_preset=”default” background_color=”#ffffff” custom_padding=”35px|35px|35px|35px|true|true” border_radii=”on|10px|10px|10px|10px” border_width_all=”1px” border_color_all=”#4E738A” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” header_4_font_size=”22px” global_colors_info=”{}”]<\/p>\n [\/et_pb_text][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.27.4″ _module_preset=”default” background_color=”#ffffff” custom_padding=”35px|35px|35px|35px|true|true” border_radii=”on|10px|10px|10px|10px” border_width_all=”1px” border_color_all=”#4E738A” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” header_4_font_size=”22px” global_colors_info=”{}”]<\/p>\n The mTOR (mechanistic target of rapamycin) pathway regulates cell growth and metabolism but can contribute to aging when overactive. Metformin inhibits mTOR, which may slow cellular aging and reduce the risk of age-related conditions like cancer and neurodegenerative diseases. It can also help modulate multiple hallmarks of aging, notably through the suppression of cellular senescence and the restoration of mitochondrial function<\/a>.<\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ custom_padding_last_edited=”on|phone” _builder_version=”4.27.4″ _module_preset=”default” custom_padding=”||||false|false” custom_padding_tablet=”||||false|false” custom_padding_phone=”||1%||false|false” global_colors_info=”{}”][et_pb_row column_structure=”1_2,1_2″ make_equal=”on” custom_padding_last_edited=”on|phone” _builder_version=”4.27.4″ _module_preset=”default” width=”90%” width_tablet=”90%” width_phone=”80%” width_last_edited=”on|phone” max_width=”100%” custom_padding=”0px||50px||false|true” custom_padding_tablet=”||10px||false|true” custom_padding_phone=”||10px||false|true” global_colors_info=”{}”][et_pb_column type=”1_2″ _builder_version=”4.27.4″ _module_preset=”default” background_image=”https:\/\/lowcountrymale.com\/wp-content\/uploads\/2022\/12\/benefits.2.lcm_.jpg” background_position=”top_center” border_radii=”on|15px|15px|15px|15px” global_colors_info=”{}” custom_css_main_element_last_edited=”on|tablet” custom_css_main_element_tablet=”min-height:300px!important;||background-position:top;||margin-bottom:20px!important;” custom_css_main_element_phone=”min-height:300px!important;||background-position:top;||margin-bottom:20px!important;”][et_pb_code _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_code][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” text_font=”|600|||||||” text_text_color=”#3f3f3f” text_font_size=”16px” header_font=”Montserrat|800|||||||” header_text_color=”#ffffff” header_font_size=”36px” header_2_font=”Montserrat|800|||||||” header_2_text_color=”#4E738A” header_2_font_size=”30px” custom_margin=”||0px||false|false” header_2_text_align_tablet=”” header_2_text_align_phone=”center” header_2_text_align_last_edited=”on|phone” global_colors_info=”{}”]<\/p>\n The potential of metformin in anti-aging has been explored in preclinical and clinical studies:<\/p>\n While these findings are promising, more research is needed to fully understand metformin\u2019s role in anti-aging, especially in healthy individuals.<\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_2,1_2″ make_equal=”on” _builder_version=”4.27.4″ _module_preset=”default” width=”90%” width_tablet=”90%” width_phone=”80%” width_last_edited=”on|phone” max_width=”100%” custom_padding=”0px||0px||true|true” global_colors_info=”{}” custom_css_main_element_last_edited=”on|tablet” custom_css_main_element_tablet=”display: flex;||flex-direction: column-reverse” custom_css_main_element_phone=”display: flex;||flex-direction: column-reverse”][et_pb_column type=”1_2″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” text_font=”|600|||||||” text_text_color=”#3f3f3f” text_font_size=”16px” header_font=”Montserrat|800|||||||” header_text_color=”#ffffff” header_font_size=”36px” header_2_font=”Montserrat|800|||||||” header_2_text_align=”left” header_2_text_color=”#4E738A” header_2_font_size=”30px” header_2_text_align_tablet=”left” header_2_text_align_phone=”center” header_2_text_align_last_edited=”on|phone” text_orientation_tablet=”” text_orientation_phone=”left” text_orientation_last_edited=”on|phone” global_colors_info=”{}”]<\/p>\n \u201cMetformin may be targeting the root cause\u201d of several other diseases whose risks increase with age, potentially because it regulates hormones, repairs tissues and eases immune system inflammation, per an article from the New York Times.<\/span><\/p>\n Based on current evidence, metformin may offer the following benefits for those seeking to optimize their aging process:<\/span><\/p>\n [\/et_pb_text][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.27.4″ _module_preset=”default” background_image=”https:\/\/lowcountrymale.com\/wp-content\/uploads\/2022\/08\/menworkingout-scaled-e1616445593951.jpeg” background_position=”top_center” border_radii=”on|15px|15px|15px|15px” global_colors_info=”{}” custom_css_main_element_last_edited=”on|tablet” custom_css_main_element_tablet=”min-height:300px!important;||background-position:top;||margin-bottom:20px!important;” custom_css_main_element_phone=”min-height:300px!important;||background-position:top;||margin-bottom:20px!important;”][et_pb_code _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_code][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ custom_padding_last_edited=”off|tablet” _builder_version=”4.27.4″ _module_preset=”default” background_color=”#e4eaed” use_background_color_gradient=”on” background_color_gradient_stops=”#e4eaed 38%|#ffffff 68%” custom_padding=”||||false|false” custom_padding_tablet=”||||false|false” custom_padding_phone=”||||false|false” border_color_all=”RGBA(255,255,255,0)” border_width_top=”3px” border_color_top=”#4E738A” border_color_bottom=”#4E738A” global_colors_info=”{}”][et_pb_row column_structure=”1_2,1_2″ custom_padding_last_edited=”on|phone” _builder_version=”4.27.4″ _module_preset=”default” max_width=”100%” custom_padding=”0px|50px|0px|50px|true|true” custom_padding_tablet=”0px|50px|0px|50px|true|true” custom_padding_phone=”|0px||0px|true|true” global_colors_info=”{}”][et_pb_column type=”1_2″ _builder_version=”4.27.4″ _module_preset=”default” custom_padding_tablet=”||||false|true” custom_padding_last_edited=”off|desktop” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” text_font=”|600|||||||” text_text_color=”#3f3f3f” text_font_size=”16px” header_font=”Montserrat|800|||||||” header_text_color=”#ffffff” header_font_size=”36px” header_2_font=”Montserrat|800|||||||” header_2_text_color=”#4E738A” header_2_font_size=”30px” width=”100%” custom_padding_tablet=”||||false|true” custom_padding_last_edited=”off|tablet” hover_enabled=”0″ text_orientation_tablet=”left” text_orientation_phone=”center” text_orientation_last_edited=”on|phone” global_colors_info=”{}” sticky_enabled=”0″]<\/p>\n In addition to the above, there is some evidence that Metformin can also help with weight loss. According to Stanford University Medicine<\/a>, Metformin produces an “anti-hunger” molecule produced after vigorous exercise is responsible for the moderate weight loss caused by the diabetes medication.<\/span><\/p>\n It can help with:<\/p>\nWhat is Metformin?<\/h2>\n
How Metformin May Support Anti-Aging<\/h3>\n
1. Reduction of Oxidative Stress<\/b><\/h4>\n
Oxidative stress, caused by an imbalance of free radicals and antioxidants, accelerates aging and age-related diseases. Metformin has been shown to reduce oxidative damage by boosting antioxidant defenses and improving mitochondrial function, which may protect cells from premature aging.<\/ul>\n
2. Improved Insulin Sensitivity<\/b><\/h4>\n
3. Anti-Inflammatory Effects<\/b><\/h4>\n
4. Activation of AMPK Pathway<\/b><\/h4>\n
Metformin activates AMP-activated protein kinase (AMPK), a critical regulator of cellular energy. AMPK helps cells use energy more efficiently, reduces inflammation, and enhances metabolic health. By mimicking the effects of caloric restriction\u2014a known longevity-promoting intervention\u2014AMPK activation may slow aging processes at the cellular level.<\/ul>\n
5. Inhibition of mTOR Pathway<\/b><\/h4>\n
Research on Metformin and Longevity<\/h2>\n
\n
\n
<\/span><\/li>\n
<\/span><\/li>\n<\/ul>\n<\/li>\n<\/ul>\nPotential Benefits for Anti-Aging<\/h2>\n
\n
\n
\n
<\/span><\/li>\nAdditional Benefits of Metformin – Weight Loss?<\/h2>\n