Your Guide to Medical Weight Loss at Lowcountry Male.
Medical Weight Loss for Men
Obesity and weight gain are complex issues influenced by hormones, metabolism, and appetite regulation. Glucagon-like peptide-1 (GLP-1) receptor agonists have emerged as groundbreaking treatments, helping individuals reduce cravings, improve insulin sensitivity, and accelerate weight loss.
At Lowcountry Male, we provide personalized GLP-1 therapy options, including Semaglutide/GLP-1, Tirzepatide, and Phentermine, to help you achieve your weight loss goals. Our specialists create custom treatment plans tailored to your health needs, ensuring optimal results. In this guide, we’ll explore how GLP-1 medications work, their benefits, potential risks, and what to expect from treatment at Lowcountry Male.
What is a GLP-1?
Glucagon-like peptide-1 (GLP-1) is a hormone produced in the intestines that plays a pivotal role in glucose metabolism and appetite regulation. It enhances insulin secretion, inhibits glucagon release, and slows gastric emptying, leading to increased satiety and reduced food intake. These effects make GLP-1 receptor agonists valuable in managing type 2 diabetes and obesity.
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How do GLP-1s work?
These medications mimic the action of the natural hormone GLP-1, which plays a crucial role in regulating appetite and blood sugar levels. By activating GLP-1 receptors, these drugs enhance insulin secretion, suppress glucagon release, slow gastric emptying, and promote a feeling of fullness, leading to reduced food intake and weight loss.
Weight Loss Treatment Options at Lowcountry Male: Semaglutide/GLP-1, Tirzepatide, and Phentermine
Semaglutide/GLP-1:
Semaglutide/GLP-1 is a GLP-1 receptor agonist that has shown significant efficacy in weight management. Studies have demonstrated that adults with overweight or obesity experienced substantial weight loss when treated with Semaglutide/GLP-1.
Tirzepatide:
Tirzepatide is a dual glucose-dependent insulinotropic polypeptide (GIP) and GLP-1 receptor agonist. Clinical trials have indicated that tirzepatide may lead to more significant weight loss than Semaglutide/GLP-1.
Phentermine:
Phentermine is an appetite suppressant that affects the central nervous system. It is commonly used short-term to assist in weight loss, typically in combination with diet and exercise. Phentermine has been among the most prescribed drugs for obesity treatment.
Benefits of GLP-1 Weight Loss Therapy
GLP-1 receptor agonists offer a range of health benefits, particularly for individuals with obesity and type 2 diabetes.
Significant Weight Reduction
Clinical trials have shown that GLP-1 receptor agonists lead to substantial weight loss. A study in The New England Journal of Medicine reported that participants taking 2.4 mg of Semaglutide/GLP-1 weekly lost an average of 14.9% of their body weight over 68 weeks when combined with lifestyle changes.
Appetite Suppression & Fullness
GLP-1 medications slow gastric emptying and reduce hunger hormones, helping patients feel fuller for longer and naturally consume fewer calories. This mechanism plays a crucial role in sustained weight loss.
Real-World Effectiveness
A large study of 2,400+ patients with obesity and type 2 diabetes found that one-third of participants lost at least 5% of their body weight over 72 weeks with GLP-1 therapy.
Risks and Side Effects of GLP-1 Therapy
While GLP-1 therapies have been shown to be effective for weight loss, it is essential to be aware of the potential risks and side effects, which may include:
Gastrointestinal Issues
Pancreatitis
In rare cases, GLP-1 medications have been linked to inflammation of the pancreas, which can cause severe abdominal pain.
Gallbladder Problems
Rapid weight loss associated with GLP-1 therapy may increase the risk of gallstones and other gallbladder-related issues.
Hypoglycemia (Low Blood Sugar)
While uncommon in non-diabetics, there is a potential risk of hypoglycemia, particularly if combined with other diabetes medications.
Thyroid Concerns
GLP-1 receptor agonists carry a warning for a potential increased risk of medullary thyroid carcinoma in animal studies, though this has not been confirmed in humans.
Injection Site Reactions
Some individuals using injectable GLP-1 medications may experience redness, swelling, or irritation at the injection site.
It’s essential to discuss potential risks with your healthcare provider to determine if GLP-1 therapy is appropriate for you and to ensure proper monitoring throughout treatment.
Who is a Good Candidate for GLP-1 Therapy?
GLP-1 treatments may be beneficial for individuals who:
- Have a BMI of 30 or higher, or 27+ with weight-related health conditions (e.g., diabetes, hypertension).
- Struggle with persistent cravings or portion control despite diet and exercise efforts.
- Experience insulin resistance or metabolic dysfunction that affects weight loss.
- Want a medically supervised, non-surgical option for sustainable weight management.
Administration of GLP-1 and Oral Weight Loss Therapies
| Semaglutide/GLP-1 and Tirzepatide These medications are typically administered via subcutaneous injection once weekly. Our healthcare team will provide training on proper injection techniques to ensure safe and effective self-administration. |
Phentermine Phentermine is usually taken orally in tablet or capsule form once daily, preferably before breakfast or 1-2 hours after breakfast. It’s intended for short-term use as part of a comprehensive weight loss plan. |
Comprehensive Evaluation at Lowcountry Male
Before initiating GLP-1 therapy or phentermine treatment, our physicians thoroughly assess the most effective and safest approach for each patient. This includes:
Medical History Review
Evaluating past and current health conditions that may impact treatment.
Comprehensive Blood Panel
Checking key biomarkers related to metabolism and overall health, including:
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- A1C Levels – Assessing blood sugar control and potential risk for diabetes.
- Thyroid Function (TSH, T3, T4) – Identifying any thyroid disorders that may affect metabolism and weight.
- Lipid Profile & Liver Function Tests – Evaluating overall metabolic health and liver function.
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Body Composition Analysis
Measuring overall body fat percentage, muscle mass, and metabolic rate to set realistic weight loss goals.
Lifestyle & Dietary Factors
Assessing daily diet, appetite regulation, and activity levels to customize treatment plans.
Heart Health & Blood Pressure Monitoring
Phentermine is not recommended for patients with high blood pressure, heart disease, or a history of cardiovascular conditions.
Medication & Supplement Review
Ensuring there are no contraindications or interactions with current prescriptions.
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Weight Loss Frequently Asked Questions
How Long Do the Effects Last After Stopping GLP-1 Therapy?
Studies have shown that discontinuing GLP-1 therapy may lead to weight regain over time. Maintaining a healthy lifestyle is crucial to sustaining weight loss achieved during treatment.
Who Should Avoid GLP-1 Therapies?
Individuals with a history of medullary thyroid carcinoma, multiple endocrine neoplasia syndrome type 2, or those with known hypersensitivity to GLP-1 receptor agonists should avoid these therapies. A thorough medical evaluation will help determine suitability.
Can Phentermine Cause Hair Loss?
While hair loss is not a commonly reported side effect of phentermine, there have been cases where individuals experienced hair shedding while using the medication. A case study documented an increase in 5-alpha-dihydrotestosterone (DHT) levels after starting phentermine, which may contribute to hair loss in some individuals.
Patients experiencing hair loss while taking phentermine should consult their healthcare provider to determine the underlying cause and discuss potential treatment options.
How Much Weight Should I Aim to Lose?
Setting realistic weight loss goals is crucial for long-term success. Aiming for a steady loss of 1 to 2 pounds per week is generally recommended. Achieving even a modest weight loss of 5% to 10% of your initial body weight can yield significant health benefits.
Does Insurance cover Medical Weight Loss Services?
Lowcountry Male does not accept most insurance plans; however, we do accept Medicare, Tricare, and BlueCross BlueShield State SC PEBA. For those without coverage, we offer low-cost, hands-on health plans that go beyond standard primary care to provide comprehensive, personalized treatment options.
Are Medical Weight Loss Treatments like Semaglutide/GLP-1, Tirzepatide, and Phentermine FDA Approved?
Yes, Semaglutide/GLP-1, Tirzepatide, and Phentermine are FDA-approved for weight loss under specific brand names and indications:
- Semaglutide/GLP-1 (Wegovy®) – FDA-approved for chronic weight management in adults with a BMI of 30 or higher, or 27 or higher with at least one weight-related condition.
- Tirzepatide (Zepbound™) – FDA-approved for chronic weight management in adults with obesity or overweight with at least one weight-related condition.
- Phentermine – FDA-approved as a short-term weight loss aid (up to 12 weeks) for individuals with obesity (BMI of 30 or higher) or overweight (BMI of 27 or higher) with a weight-related condition. It is commonly prescribed as Adipex-P® or in combination with topiramate (Qsymia®) for extended weight management.
Can I Combine Semaglutide/GLP-1, Tirzepatide, and Phentermine for Weight Loss?
- Semaglutide/GLP-1 & Tirzepatide – There is no clinical evidence supporting the combined use of Semaglutide/GLP-1 (Wegovy®) and tirzepatide (Zepbound™) for weight loss. While both medications act as GLP-1 receptor agonists, tirzepatide also targets the GIP receptor. Due to their overlapping mechanisms, combining these drugs is not recommended, and this approach has not been studied in clinical trials.
- Phentermine & GLP-1 Medications – Phentermine, a stimulant-based appetite suppressant, works through a different mechanism than GLP-1 receptor agonists. Some healthcare providers may prescribe phentermine alongside Semaglutide/GLP-1 or tirzepatide in specific cases, but this combination has limited clinical research and should be used only under medical supervision.
When will I start seeing results?
Semaglutide/GLP-1
- Initial Results: Patients may begin to notice weight loss within the first 3 months of treatment.
- Significant Milestones: Clinical studies have shown an average weight loss of 5.9% at 3 months and 10.9% at 6 months.
- Long-Term Outcomes: Extended trials indicate that patients can achieve up to 14.9% weight loss over 68 weeks.
Tirzepatide
- Initial Results: Weight loss effects may become noticeable within the first 12 weeks.
- Significant Milestones: Studies have reported an average weight loss of 20.9% at 36 weeks.
- Long-Term Outcomes: Continued use has shown additional weight loss, with some patients achieving up to 25% reduction in body weight over 88 weeks.
Phentermine
- Initial Results: Phentermine is typically prescribed for short-term use, and weight loss can be observed within the first few weeks.
- Significant Milestones: Patients may experience an average weight loss of 5-10% of their starting weight over 12-14 weeks.
- Usage Duration: Due to its stimulant properties, phentermine is generally approved for use up to 12 weeks.
It’s important to note that individual results can vary based on factors such as adherence to the medication regimen, lifestyle modifications, and underlying health conditions. Consulting with a healthcare provider is essential to determine the most appropriate treatment plan and to set realistic expectations for weight loss outcomes.