Tesamorelin: A Smarter Way to Reduce and Burn Fat & Improve Sleep

As men age, metabolism slows, energy dips, and stubborn abdominal fat can become harder to lose. At Lowcountry Male, we specialize in cutting-edge therapies that help restore your vitality from the inside out. One of the most effective treatments in our arsenal is Tesamorelin—a clinically-backed peptide designed to naturally boost your body’s growth hormone production and support long-term metabolic health.

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What is Tesamorelin?

Tesamorelin is a synthetic version of Growth Hormone–Releasing Hormone (GHRH). It consists of the same 44 amino acids found in natural human GHRH. Rather than replacing hormones directly, it works by stimulating your pituitary gland to produce more of your body’s own natural growth hormone.

This unique approach supports metabolism, muscle tone, and fat reduction without the risks associated with traditional hormone replacement therapies.

Originally studied during the AIDS crisis, it was approved to treat HIV-associated lipodystrophy, Tesamorelin has shown broad benefits for men experiencing age-related declines in growth hormone, metabolism, and body composition.

How Tesamorelin Works

After age 30, natural growth hormone levels begin to drop – sometimes by as much as 15% per decade. This decline contributes to slower metabolism, increased belly fat, and decreased energy. Tesamorelin helps reverse those effects by:

Stimulating the pituitary gland to release more GH naturally
Raising IGF-1 levels, a key hormone for muscle and fat metabolism
Supporting lipolysis, the body’s process of burning stored fat for fuel

The result? Improved energy, lean muscle support, and a noticeable reduction in stubborn abdominal fat.

According to the New England Journal of Medicine, daily tesamorelin for 26 weeks decreased visceral fat and improved lipid profiles, effects that might be useful in patients who have treatment-associated central fat accumulation.

What Are the Benefits of Tesamorelin Therapy?

Men who use Tesamorelin under the supervision of our clinical team at Lowcountry Male often notice:

Reduced abdominal fat and visceral fat
Improved muscle tone and recovery
Enhanced metabolism and fat-burning efficiency
Better sleep and cognitive function
Support for healthy aging and vitality

Research shows that tesamorelin can significantly decrease visceral fat – fat that surrounds your organs – which is much more prominent in men. Findings showed: Treatment with tesamorelin reduces VAT (visceral adipose tissue) and maintains the reduction for up to 52 weeks, and also improves body image and lipids, and is overall well tolerated without clinically meaningful changes in glucose parameters.

These benefits are even more pronounced when combined with proper nutrition, strength training, and other hormone optimization strategies. Be sure to discuss these with one of our providers for the best peptide for the therapy that’s right for you.

When to Expect Results

Most patients start noticing subtle improvements in 4–6 weeks, with more visible changes after about 12 weeks.

Full results—including measurable changes in body composition—are typically achieved within 3–6 months of consistent therapy.

Experience the Lowcountry Male Difference

At Lowcountry Male, we combine precision medicine, advanced peptide therapy, and personalized hormone optimization to help men reclaim their energy, confidence, and performance.

If you’re ready to take control of your health and target stubborn belly fat from the inside out, schedule a consultation today to see if Tesamorelin therapy is right for you.

About Lowcountry Male and AquaVitae

Founded in 2016, Lowcountry Male and AquaVitae specialize in men’s and women’s health, offering advanced treatments in TRT, BHRT, peptides, anti-aging, weight loss, and more. With a focus on personalized care and innovative therapies, the clinics have served thousands of patients across seven locations in South Carolina and one in Georgia, in the following cities: Anderson, Charleston, Fort Mill, Greenville, Mount Pleasant, Myrtle Beach, Savannah and Spartanburg.

Tesamorelin FAQS

Our team of clinical experts have answers.

Can Tesamorelin Help Burn Fat More Efficiently?

Yes. Because growth hormone plays a direct role in lipolysis, the process of breaking down triglycerides (stored fat) into free fatty acids that your body can use for energy is increased.

This means Tesamorelin helps your body shift from storing fat to burning it, especially around the abdomen and visceral area (the deep belly fat surrounding internal organs). In a study, tesamorelin showed to be 3.9 times greater in doing this than patients receiving a placebo.

By raising IGF-1 (Insulin-like Growth Factor 1) levels, Tesamorelin also helps preserve lean muscle mass while reducing fat. This means your resting metabolism improves – muscle burns more calories than fat, even at rest – leading to more efficient long-term fat burning.

How Does Tesamorelin Help Sleep?

Because Tesamorelin is a growth hormone–releasing hormone (GHRH) analog, it may support better sleep by stimulating the body’s natural production of growth hormone, which is closely tied to deep, restorative slow-wave sleep. GHRH itself has been shown in studies to promote non-REM sleep and improve sleep quality.

Benefits may also come indirectly through better metabolism, reduced visceral fat, and enhanced recovery. However, sleep disturbances like insomnia can occur in some individuals, so results can vary. Be sure to consult with your provider if you experience sleep problems after starting tesamorelin.

Is Tesamorelin Right for You?

Tesamorelin may be ideal if you’re:

Struggling with stubborn abdominal fat despite regular exercise
Experiencing low energy or slow metabolism
Looking for a natural, non-replacement way to support hormone health
Interested in improving your body composition and recovery

At Lowcountry Male, we tailor every treatment plan to your unique lab results, lifestyle, and goals.

Is Tesamorelin Safe?

Tesamorelin is generally well tolerated. Minor side effects, such as injection site irritation or mild water retention, are usually short-lived. Because this therapy influences hormone pathways, it’s important that it be prescribed and monitored by a licensed medical provider.

Our team performs comprehensive bloodwork labs and follow-ups to ensure your treatment stays effective, safe, and optimized for your results.

For a list of potential side effects, see the page on tesamorelin at the Mayo Clinic.